Vol. 5, Issue 4 (2020)
Preparation and characterization of cilnidipine hydroxypropyl-b-cyclodextrin inclusion complex by solvent evaporation to enhance oral-solubility of drug
Author(s): Tulaja Kadam, Snehal Thakar, Deepali Bansode
Abstract: The aim of this work was to improve the water-solubility of cilnidipine by complexing it with hydroxypropyl-b-cyclodextrin. Cilnidipine, a novel fourth generation calcium channel blocker, which is poorly water soluble with low bioavailability. Cilnidipine needs enhancement of dissolution rate and solubility to improve its oral bioavailability and therapeutic efficacy. The objective of this research was to prepare the inclusion complex by solvent evaporation method, evaluate the complex and to characterize it by Phase solubility method, FTIR, DSC, SEM and XRD studies. DSC and XRD analyses indicated the complete transformation of Cilnidipine in the complex from crystalline to amorphous state. The solubility of cilnidipine increased linearly as a function of HP-b-CD concentration. The results identified the cilnidipine-HP-b-CD inclusion complex as an effective new method to design a novel formulation for pharmaceutical application. It also designated that the bioavailability of cilnidipine could be improved markedly by inclusion complexation, possibly due to an increased dissolution rate.