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International Journal of Pharmaceutical Science and Research


ISSN: 2455-4685

Vol. 1, Issue 2 (2016)

The effect of erythropoietin on oophoritis during ischemia reperfusion injury in rats

Author(s): C. Τsompos, C. Panoulis, K Τοutouzas, A. Triantafyllou, G. Ζografos, A. Papalois
Abstract: Background: This experimental study examined the effect of erythropoietin on rat model and particularly in an ovarian ischemia reperfusion (IR) protocol. The effects of that molecule were studied pathologically using mean oophoritis (OI) lesions.
Materials and methods: 40 rats of mean weight 247.7 g were used in the study. OI lesions were evaluated at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion. Erythropoietin was administered only in groups C and D.
Results: Epo administration did not alter the OI scores. The increase in OI scores was 0.15 without lesions [-0.0158339 - 0.3158339] (p=0.0791). Reperfusion kept non-significantly increased the OI scores by 0.15 without lesions [-0.0158339 - 0.3158339] (P=0.0791). Together, the Epo administration and reperfusion kept significantly increased the OI scores by 0.1363636 without lesions [0.0421443 - 0.230583] (p=0.0057).
Conclusions: Epo administration particularly in concert with reperfusion kept significantly increased the OI score lesions in ovaries after experimental ischemia in rats.
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